One monitor will be fine no matter the resolution.

Hey I will give my anecdotal recent experience. Several months ago I switched to Pop! OS and have had basically no issues. I have an Nvidia GPU and I play a lot of games. I don’t play any games that are blocked by anti cheat (not because I can’t, I just don’t happen to play the few that are blocked).

I spent the first day getting everything signed in, installed, set up and tweaked to how I like it with very minimal terminal usage. Mostly gui and clicking.

Steam+Proton along with lutris makes it easy to play any game for me.

Side note: I have 4 monitors of varying resolution, size, orientation and refresh rate and it hasn’t caused problems other than the initial setup (I used cursr to help with this)