You can install all the M$ Store and Xbox apps. Afterwards the XBox app will tell you all the other apps missing and a 1 click button to install each. It’s just a nice clean blank slate to start with. It doesn’t even have .net or vcredist installed.
What missing feature sets?
Edit: I myself install 2 needed dependencies to get Winget running after a fresh install. One has to do with UWP.
I’ve had a lot more success using Bottles over Lutris. Being able to see a list of all possible Windows dependencies and being able to 1 click install any of them is aces. The default Gaming Bottle itself is very good, but I’m not sure how their own custom runner, Soda, performs.